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Aspergillic acid : ウィキペディア英語版 | Aspergillic acid
Aspergillic acid is an organic chemical compound with the molecular formula C12H20N2O2. It has a pale yellow crystalline appearance. Aspergillic acid is most commonly known as an antibiotic and antifungal agent that is derived from certain strains of the fungus ''Aspergillus flavus''.〔http://www.jbc.org/content/236/2/512.full.pdf〕 == History == In 1940 Edwin C. White and Justina H. Hill discovered that a fungal strain of ''Aspergillus flavus'' growing in a surface culture on a tryptone-salt was capable of producing a bactericidal filtrate. It has also been shown to be a bactericidal for some Gram-negative as well as Gram-positive bacteria. Over the next few years they worked off this discovery and succeeded to isolate the active material in the crystalline form. In 1943 they managed to isolate this antibiotic compound and called it aspergillic acid primarily because of its origin and acidic properties. Scientists have since been working with the ''Asperigillus flavus ''strain to produce various types of antibacterial substances.〔http://www.jbc.org/content/171/1/321.full.pdf〕〔http://pubs.acs.org/doi/pdf/10.1021/jo01350a062〕
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